The d-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism and Bone and Blood Lead Levels in Community-Exposed Men: The Normative Aging Study
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چکیده
منابع مشابه
The delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bone and blood lead levels in community-exposed men: the Normative Aging Study.
Recent research has indicated that a polymorphic variant of delta-aminolevulinic acid dehydratase (ALAD) may influence an individual's level of lead in bone and blood and, as a result, may also influence an individual's susceptibility to lead toxicity. In this study, we investigated whether this ALAD polymorphism is associated with altered levels of lead in bone and blood among 726 middle-aged ...
متن کاملOriginal Contribution Lead Burden and Psychiatric Symptoms and the Modifying Influence of the d-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism The VA Normative Aging Study
1 Department of Environmental Health, Harvard School of Public Health, Boston, MA. 2 Bureau of Environmental Disease Prevention, Division of Environmental Health, New York City Department of Health and Mental Hygiene, New York, NY. 3 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA. 4 Center for Environmental Health and Technology, Brown University, Provi...
متن کاملDelta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).
BACKGROUND AND OBJECTIVE Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this...
متن کاملDeterminants of bone and blood lead levels among community-exposed middle-aged to elderly men. The normative aging study.
Levels of lead in bone serve as a dosimeter for cumulative exposure to lead; moreover, lead in bone may serve as an internal source of circulating lead many years after environmental exposure has ceased. The authors measured lead in blood and used a K-x-ray fluorescence instrument to measure lead in the tibia (cortical) and patella (trabecular) bones in a cross-sectional survey of 719 middle-ag...
متن کاملA delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study.
In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function among middle-aged and elderly men. We performed a cross-sectional study of subjects who participated between 1991 and 1995 in the Department of Veterans Affairs Normative A...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2001
ISSN: 0091-6765
DOI: 10.2307/3454826